Table 4.
Logistic Regression of Presence of Liver Enzyme Abnormalities (Baseline or Follow-up) among HIV-Infected Persons without a Known Cause of Liver Disease
| LFT Abnormality | Univariate logistic regression |
Multivariate logistic regression1 |
||||
|---|---|---|---|---|---|---|
| Characteristic | Yes | No | Odds ratio |
P- value |
Odds ratio |
P- value |
| Age2,3 | 41.0 (35.0, 48.0) | 38.0 (28.0, 46.0) | 1.26 | .14 | ||
| Female | 3 (7.3%) | 11 (7.8%) | 0.93 | .92 | ||
| White | 17 (41.5%) | 67 (47.5%) | ||||
| African American | 13 (31.7%) | 46 (32.6%) | 1.11 | .80 | ||
| Latino/Hispanic | 7 (17.1%) | 16 (11.3%) | 1.72 | .30 | ||
| Other race | 4 (9.8%) | 12 (8.5%) | 1.31 | .67 | ||
| Illicit drug use | 2 (4.9%) | 3 (2.1%) | 2.36 | .36 | ||
| Daily acetaminophen | 2 (4.9%) | 7 (5.0%) | 0.98 | .98 | ||
| Duration of HIV Infection (years)2 | 14 (5, 20) | 8 (3, 13) | 1.52 | .009 | ||
| Nadir CD4 count (cells/mm3)2,4 | 225 (48, 316) | 318 (187, 398) | 0.85 | .003 | 0.91 | .15 |
| Current CD4 count (cells/mm3)2,5 | 474 (354, 616) | 520 (388, 680) | 0.75 | .38 | ||
| HIV-RNA (log10 copies/mL)2 | 1.7 (1.7, 3.5) | 1.7 (1.7, 3.8) | 0.93 | .64 | ||
| On NRTI | 31 (75.6%) | 91 (64.5%) | 1.70 | .19 | ||
| On PI | 22 (53.7%) | 46 (32.6%) | 2.39 | .02 | 1.65 | .26 |
| On NNRTI | 11 (26.8%) | 47 (33.3%) | 0.73 | .43 | ||
| Body mass index (kg/m2)2 | 24.4 (23.2, 28.0) | 25.4 (23.1, 27.6) | 0.93 | .74 | ||
| Waist size2,6 | 88.0 (83.0, 97.0) | 89.0 (81.8, 94.0) | 1.07 | .68 | ||
| Total cholesterol(mg/dl)2,7 | 195 (178, 234) | 175 (156, 210) | 1.72 | .003 | 1.62 | .01 |
| HDL (mg/dl)2,8 | 46 (37, 51) | 40 (33, 46) | 1.32 | .05 | ||
| LDL (mg/dl)2,9 | 122 (96, 149) | 110 (90, 128) | 1.38 | .04 | ||
| Triglycerides (mg/dl)2,10 | 125 (90, 194) | 104 (71, 178) | 2.17 | .11 | ||
| Metabolic syndrome | 4 (9.8%) | 20 (14.2%) | 0.65 | .46 | ||
| On lipid-lowering medications | 12 (29.3%) | 31 (22.0%) | 1.47 | .34 | ||
| On diabetes medication | 1 (2.4%) | 6 (4.3%) | 0.56 | .60 | ||
| On antihypertensive medication | 13 (31.7%) | 30 (21.3%) | 1.72 | .17 | ||
1
Odds ratios are from the multivariate logistic regression of the presence of abnormality on selected characteristics, based on results from the univariate logistic regressions.
2
Median (IQR).
3
Odds ratio based on square root.
4
Odds ratio based on 50 cell difference.
5
Odds ratio based on 10 cell difference (square root).
6
Odds ratio based on 10 cm difference.
7
Odds ratio based on 40 mg/dl difference.
8
Odds ratio based on 10 mg/dl difference.
9
Odds ratio based on 30 mg/dl difference.
10
Odds ratio based on 10 mg/dl difference (square root).