Table 4.
LFT Abnormality | Univariate logistic regression |
Multivariate logistic regression1 |
||||
---|---|---|---|---|---|---|
Characteristic | Yes | No | Odds ratio |
P- value |
Odds ratio |
P- value |
Age2,3 | 41.0 (35.0, 48.0) | 38.0 (28.0, 46.0) | 1.26 | .14 | ||
Female | 3 (7.3%) | 11 (7.8%) | 0.93 | .92 | ||
White | 17 (41.5%) | 67 (47.5%) | ||||
African American | 13 (31.7%) | 46 (32.6%) | 1.11 | .80 | ||
Latino/Hispanic | 7 (17.1%) | 16 (11.3%) | 1.72 | .30 | ||
Other race | 4 (9.8%) | 12 (8.5%) | 1.31 | .67 | ||
Illicit drug use | 2 (4.9%) | 3 (2.1%) | 2.36 | .36 | ||
Daily acetaminophen | 2 (4.9%) | 7 (5.0%) | 0.98 | .98 | ||
Duration of HIV Infection (years)2 | 14 (5, 20) | 8 (3, 13) | 1.52 | .009 | ||
Nadir CD4 count (cells/mm3)2,4 | 225 (48, 316) | 318 (187, 398) | 0.85 | .003 | 0.91 | .15 |
Current CD4 count (cells/mm3)2,5 | 474 (354, 616) | 520 (388, 680) | 0.75 | .38 | ||
HIV-RNA (log10 copies/mL)2 | 1.7 (1.7, 3.5) | 1.7 (1.7, 3.8) | 0.93 | .64 | ||
On NRTI | 31 (75.6%) | 91 (64.5%) | 1.70 | .19 | ||
On PI | 22 (53.7%) | 46 (32.6%) | 2.39 | .02 | 1.65 | .26 |
On NNRTI | 11 (26.8%) | 47 (33.3%) | 0.73 | .43 | ||
Body mass index (kg/m2)2 | 24.4 (23.2, 28.0) | 25.4 (23.1, 27.6) | 0.93 | .74 | ||
Waist size2,6 | 88.0 (83.0, 97.0) | 89.0 (81.8, 94.0) | 1.07 | .68 | ||
Total cholesterol(mg/dl)2,7 | 195 (178, 234) | 175 (156, 210) | 1.72 | .003 | 1.62 | .01 |
HDL (mg/dl)2,8 | 46 (37, 51) | 40 (33, 46) | 1.32 | .05 | ||
LDL (mg/dl)2,9 | 122 (96, 149) | 110 (90, 128) | 1.38 | .04 | ||
Triglycerides (mg/dl)2,10 | 125 (90, 194) | 104 (71, 178) | 2.17 | .11 | ||
Metabolic syndrome | 4 (9.8%) | 20 (14.2%) | 0.65 | .46 | ||
On lipid-lowering medications | 12 (29.3%) | 31 (22.0%) | 1.47 | .34 | ||
On diabetes medication | 1 (2.4%) | 6 (4.3%) | 0.56 | .60 | ||
On antihypertensive medication | 13 (31.7%) | 30 (21.3%) | 1.72 | .17 |
Odds ratios are from the multivariate logistic regression of the presence of abnormality on selected characteristics, based on results from the univariate logistic regressions.
Median (IQR).
Odds ratio based on square root.
Odds ratio based on 50 cell difference.
Odds ratio based on 10 cell difference (square root).
Odds ratio based on 10 cm difference.
Odds ratio based on 40 mg/dl difference.
Odds ratio based on 10 mg/dl difference.
Odds ratio based on 30 mg/dl difference.
Odds ratio based on 10 mg/dl difference (square root).