Table 3.

Association Between the rs2298122 Single Nucleotide Polymorphism in the Calcyon Neuron-Specific Vesicular Protein Gene (CALY) and Initiation of Smoking, by Gender, Wuhan Smoking Prevention Trial (1998–1999) and the Children's Health Study (1993–2009), China and California

Study and Gender	SNP Type	Minor Allele Frequency	Model	Odds Ratio or HRRa	95% Confidence Interval	Crude P Value	Adjusted P Valueb
Wuhan Smoking Prevention Trial
Male	Genotyped	0.07	Additive	0.88	0.63, 1.21	0.427	0.680
Female	Genotyped	0.06	Additive	2.21	1.49, 3.27	8.39 × 10−5	4.10 × 10−4
Total	Genotyped	0.07	Additive	1.30	1.00, 1.68	0.049	0.553
Children's Health Study
Male	Genotyped	0.18	Additive	1.32	0.78, 2.23	0.304	NA
Female	Genotyped	0.20	Additive	2.05	1.27, 3.31	0.003	NA
Total	Genotyped	0.19	Additive	1.69	1.19, 2.4	0.004	NA

Abbreviations: HRR, hazard rate ratio; NA, not applicable; SNP, single nucleotide polymorphism.

^aOdds ratio (Wuhan Smoking Prevention Trial) or HRR (Children's Health Study) estimate for the SNP with the putative heredity model.

^bP value after accounting for the multiple testing due to heredity model selection and multiple SNPs in the given gene region.