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. 2011 Mar 29;173(10):1171–1182. doi: 10.1093/aje/kwq491

Table 3.

Associations Between Dietary Intake and Breast Cancer Risk, Shanghai Women's Health Study, 1997–2008

Nutrient Quintile of Dietary Intake
 P for Trend
1 (Low) 2 3 4 5
All Womenab
Folate
    Mean intake, μg/day 194 243 282 328 404
    Cases, n 146 142 143 160 127
    HR 1.0 0.90 0.89 0.99 0.79 0.32
    95% CI Ref 0.71, 1.15 0.69, 1.15 0.76, 1.28 0.59, 1.06
Methionine
    Mean intake, g/day 1.13 1.34 1.48 1.65 1.97
    Cases, n 140 146 141 150 141
    HR 1.0 0.98 0.94 0.98 0.92 0.68
    95% CI Ref 0.76, 1.26 0.71, 1.23 0.73, 1.32 0.66, 1.28
Vitamin B12
    Mean intake, μg/day 1.00 1.83 2.44 3.11 4.60
    Cases, n 143 139 145 152 139
    HR 1.0 0.89 0.88 0.91 0.83 0.35
    95% CI Ref 0.69, 1.14 0.68, 1.15 0.69, 1.19 0.61, 1.12
Vitamin B6
    Mean intake, mg/day 1.23 1.50 1.67 1.88 2.23
    Cases, n 126 167 138 140 147
    HR 1.0 1.26 1.01 1.02 1.05 0.57
    95% CI Ref 0.98, 1.61 0.77, 1.33 0.76, 1.36 0.76, 1.46
Niacin (vitamin B3)
    Mean intake, mg/day 11.7 12.9 13.9 15.1 17.6
    Cases, n 132 146 148 147 145
    HR 1.0 1.06 1.06 1.05 1.05 0.81
    95% CI Ref 0.83, 1.35 0.82, 1.37 0.80, 1.39 0.78, 1.42
Riboflavin (vitamin B2)
    Mean intake, mg/day 0.55 0.72 0.84 0.98 1.16
    Cases, n 131 138 159 145 145
    HR 1.0 0.98 1.08 0.94 0.93 0.55
    95% CI Ref 0.76, 1.27 0.82, 1.42 0.70, 1.27 0.66, 1.30
Premenopausal Womena
Folate
    Cases, n 55 31 45 42 40
    HR 1.00 0.45 0.63 0.59 0.58 0.22
    95% CI Ref 0.29, 0.72 0.40, 0.98 0.37, 0.95 0.34, 0.99
Methionine
    Cases, n 41 38 41 45 48
    HR 1.00 0.72 0.73 0.80 0.81 0.82
    95% CI Ref 0.45, 1.16 0.44, 1.20 0.47, 1.35 0.45, 1.45
Vitamin B12
    Cases, n 30 38 42 49 54
    HR 1.00 0.93 0.93 1.03 1.02 0.73
    95% CI Ref 0.56, 1.52 0.56, 1.55 0.61, 1.73 0.59, 1.78
Vitamin B6
    Cases, n 32 48 41 37 55
    HR 1.00 1.25 1.02 0.90 1.34 0.75
    95% CI Ref 0.78, 2.00 0.61, 1.71 0.52, 1.57 0.74, 2.42
Niacin (vitamin B3)
    Cases, n 36 32 47 38 60
    HR 1.00 0.73 1.01 0.80 1.28 0.24
    95% CI Ref 0.45, 1.20 0.63, 1.62 0.48, 1.33 0.76, 2.18
Riboflavin (vitamin B2)
    Cases, n 32 44 47 43 47
    HR 1.00 1.06 1.05 0.95 1.00 0.81
    95% CI Ref 0.65, 1.72 0.63, 1.76 0.54, 1.65 0.54, 1.85
Postmenopausal Womena
Folate
    Cases, n 66 72 67 80 61
    HR 1.00 1.20 1.12 1.29 0.97 0.98
    95% CI Ref 0.84, 1.71 0.77, 1.63 0.89, 1.89 0.63, 1.49
Methionine
    Cases, n 81 72 69 71 53
    HR 1.00 1.01 1.04 1.08 0.87 0.72
    95% CI Ref 0.71, 1.44 0.70, 1.54 0.71, 1.65 0.53, 1.42
Vitamin B12
    Cases, n 93 75 70 59 49
    HR 1.00 0.86 0.84 0.74 0.70 0.10
    95% CI Ref 0.62, 1.19 0.59, 1.20 0.50, 1.10 0.45, 1.09
Vitamin B6
    Cases, n 71 89 63 65 58
    HR 1.00 1.39 1.03 1.07 0.96 0.38
    95% CI Ref 0.99, 1.95 0.70, 1.52 0.70, 1.61 0.60, 1.54
Niacin (vitamin B3)
    Cases, n 78 77 69 68 54
    HR 1.00 1.09 1.04 1.11 0.93 0.82
    95% CI Ref 0.78, 1.52 0.72, 1.49 0.75, 1.64 0.60, 1.44
Riboflavin (vitamin B2)
    Cases, n 82 70 76 59 59
    HR 1.00 0.90 0.98 0.71 0.72 0.11
    95% CI Ref 0.64, 1.29 0.68, 1.43 0.47, 1.09 0.44, 1.17

Abbreviations: CI, confidence interval; HR, hazard ratio; Ref, reference.

a

Adjusted for age at baseline (years), age at menarche (years), parity (ever, never), age at first livebirth (years), educational attainment (college or above, high school, middle school, less than middle school), physical activity (metabolic equivalent-hours/week per year), use of a B vitamin supplement (never, ever), height (m), and total daily intakes of energy (kcal), vegetables (g), and fat (g).

b

Additionally adjusted for menopausal status (no, yes).