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. 2011 Mar 29;173(10):1171–1182. doi: 10.1093/aje/kwq491

Table 5.

Association Between Dietary Intake and Risk of ER−/PR− and ER+/PR+ Breast Cancer, Shanghai Women's Health Study, 1997–2008

Quartile of Daily Dietary Intakea
 P for Trend
1 (Low) 2 3 4
ER−/PR− Breast Cancer
Folate
    Mean intake, μg/day 200 258 310 393
    Events, n 43 53 30 44
        HR 1.0 1.09 0.60 0.84 0.19
        95% CI Ref 0.71, 1.68 0.36, 1.01 0.50, 1.43
Methionine
    Mean intake, g/day 1.16 1.39 1.59 1.92
    Events, n 35 45 50 40
        HR 1.0 1.21 1.33 1.05 0.92
        95% CI Ref 0.74, 1.98 0.78, 2.27 0.56, 1.97
Vitamin B12
    Mean intake, μg/day 1.21 2.06 2.84 4.36
    Events, n 44 32 47 47
        HR 1.0 0.65 0.90 0.85 0.98
        95% CI Ref 0.40, 1.05 0.55, 1.45 0.50, 1.45
Vitamin B6
    Mean intake, mg/day 1.27 1.57 1.80 2.18
    Events, n 39 51 39 41
        HR 1.0 1.12 0.79 0.76 0.18
        95% CI Ref 0.71, 1.76 0.47, 1.34 0.42, 1.38
Niacin (vitamin B3)
    Mean intake, mg/day 11.9 13.3 14.6 17.2
    Events, n 41 46 43 40
        HR 1.0 0.98 0.86 0.76 0.27
        95% CI Ref 0.63, 1.52 0.53, 1.40 0.44, 1.31
Riboflavin (vitamin B2)
    Mean intake, mg/day 0.58 0.76 0.93 1.13
    Events, n 37 47 37 49
        HR 1.0 1.17 0.88 1.11 0.95
        95% CI Ref 0.73, 1.88 0.51, 1.51 0.61, 2.02
ER+/PR+ Breast Cancer
Folate
    Events, n 60 76 93 62
     HR 1.0 1.26 1.54 1.09 0.55
     95% CI Ref 0.88, 1.80 1.06, 2.23 0.71, 1.67
Methionine
    Events, n 79 76 93 62
     HR 1.0 0.81 0.80 0.87 0.66
     95% CI Ref 0.57, 1.16 0.54, 1.20 0.56, 1.37
Vitamin B12
    Events, n 81 66 68 76
     HR 1.0 0.87 0.88 0.93 0.81
     95% CI Ref 0.61, 1.24 0.60, 1.29 0.61, 1.40
Vitamin B6
    Events, n 74 82 56 79
     HR 1.0 1.02 0.68 0.93 0.40
     95% CI Ref 0.72, 1.44 0.45, 1.02 0.60, 1.45
Niacin (vitamin B3)
    Events, n 65 74 67 85
     HR 1.0 1.20 1.04 1.62 0.04
     95% CI Ref 0.84, 1.71 0.70, 1.55 1.07, 2.46
Riboflavin (vitamin B2)
    Events, n 68 74 82 67
     HR 1.0 1.01 1.04 0.83 0.46
     95% CI Ref 0.70, 1.46 0.70, 1.54 0.52, 1.33

Abbreviations: CI, confidence interval; ER, estrogen receptor; HR, hazard ratio; PR, progesterone receptor; Ref, reference.

a

Adjusted for age at baseline (years), age at menarche (years), parity (ever, never), age at first livebirth (years), educational attainment (college or above, high school, middle school, less than middle school), physical activity (metabolic equivalent-hours/week per year), use of a B vitamin supplement (never, ever), height (m), and total daily intakes of energy (kcal), vegetables (g), and fat (g).