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Uptake of ciclesonide into A549 cells (derived from data of Nonaka et al 2007)
| Incubation time (min) | Mean concentration (pmol/dish) | Standard deviation |
|---|---|---|
| 3 | 15.51 | 2.62 |
| 5 | 18.19 | 2.34 |
| 10 | 37.32 | 23.51 |
| 20 | 35.31 | 9.09 |
| 30 | 50.33 | 5.12 |
Notes: Intracellular concentrations of total ciclesonide (sum of ciclesonide, desisobutyryl-ciclesonide [des-CIC], and des-CIC fatty acid esters) in A549 cells during incubation with 2 × 10−8 M ciclesonide (5 dishes per time point).
