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. 2011 May 3;286(25):22227–22234. doi: 10.1074/jbc.M111.228874

FIGURE 5.

FIGURE 5.

SIRT1 protein in JNK1-KO mice. A, SIRT1 protein in liver tissues is shown. JNK1-KO mice were fed HFD for 22 weeks. SIRT1 protein was determined in the liver tissue homogenate. B, shown is protection of JNK1-KO mice from development of fatty liver. Hepatic steatosis is indicated by liver size (picture) and lipid droplet (slide with hematoxylin and eosin staining). C, triglyceride in liver is shown. D, body weight (BW) is shown. The data in panels C and D are presented as the means ± S.E. (n = 8). E, SIRT1 in lean JNK1-KO mice is shown. SIRT1 protein was determined in the liver of mice on chow diet. F, SIRT1 in lean JNK2-KO mice is shown. SIRT1 protein was determined in the liver of mice on chow diet. G, SIRT1 in obese mice with liver-specific JNK1/2 KO. SIRT1 protein was determined in the liver of double KO mice at 16 weeks on HFD. *, p < 0.05; **, p < 0.001 by Student's t test.