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PA activity of medium conditioned by bone marrow-derived macrophages and explanted aortae. Medium conditioned by macrophages (A) or aortae (B) of Ldlr−/− mice (either nontransgenic (0/0) or hemizygous for the SR-uPA transgene (+/0)) was assayed for PA activity by the addition of plasminogen and the plasmin substrate S-2251. Data points are values from individual mice; bars are group means. p values are from the Mann-Whitney test.
