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. 2011 May 2;286(25):22665–22677. doi: 10.1074/jbc.M110.202135

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Aortic root atherosclerosis in 25-week-old mice. Aortic roots from Ldlr^−/− Plaur^+/+ or Ldlr^−/− Plaur^−/− mice (either nontransgenic (0/0) or hemizygous for the SR-uPA transgene (+/0)) were sectioned and stained, and lesions were measured. A, the intimal lesion area is shown. Data points are values from individual mice; bars are group means. B–E, representative sections are from each of the genotypes and hematoxylin- and eosin-stained; size bars = 500 μm. p values are from t tests except for comparison of SR-uPA^+/0 Plaur^+/+ versus SR-uPA^0/0 Plaur^+/+ groups (Mann-Whitney test).