Skip to main content
. 2011 Jun 20;60(7):1901–1906. doi: 10.2337/db11-0120

FIG. 2.

FIG. 2.

Whole-body and hypothalamic sustained hyperglycemia impair CNS glucose effectiveness to increase hypothalamic glucose concentration and lower glucose production. A: Plasma glucose levels before clamp studies after the 24-h intravenous infusion period (whole-body glucotoxicity). *P < 0.01 vs. control. B: Glucose production. C: Hypothalamic glucose concentration. D: Glucose production. *P < 0.0001 vs. other groups. E: Hypothalamic glucose concentration. *P < 0.05 vs. other groups. F: Glucose production. G: Hypothalamic glucose concentration. i.h., intrahypothalamic; i.v., intravenous.