TABLE 3.
Top five most significantly overrepresented TFBS modules
| TFBS module | Strand | Common to sequences (%) | P value |
|---|---|---|---|
| HOMF_HOMF_ETSF | + − + | 51 | 6.58E-07 |
| HOXF_LHXF_HOXF | − − + | 58 | 6.22E-04 |
| HOXF_HBOX_HBOX | − − + | 56 | 1.47E-03 |
| HBOX_LHXF_HOXF | − − + | 51 | 2.01E-03 |
| OCT1_LHXF_HOXF | + − + | 51 | 2.41E-03 |
Five promoter modules consisting of three elements were significantly overrepresented in the promoter sequences of lipid metabolism–related genes. Module matrix families, strand orientation, percent of promoter sequences containing the module, and P values of enrichment are shown. The P value is the probability of finding the module in a set of randomly selected promoters and is determined by scanning a background promoter sequence set of 5,000 human promoters.