TABLE 1.
Diabetes complications: miRNAs and their targets
| Complication | Known targets | Reference |
|---|---|---|
| Diabetic nephropathy miR-21 | PTEN | (29) unpublished* |
| miR-29 family | Collagens | (25) unpublished* |
| miR-192 | ZEB2, Col 1 | (16,18,22,23) |
| miR-93 | VEGF | (34) |
| miR-200 family | ZEB1, ZEB2, TGF-β2 | (18,19) |
| miR-216a | YB-1, PTEN | (15,26) |
| miR-377 | PAK1, MnSOD | (30) |
| Retinopathy | ||
| miR-93, miR-200, and miR-29 families? | VEGF | (34) indirect† |
| Atherosclerosis | ||
| miR-16 | COX-2 | (39) indirect† |
| miR-503? | CCNE1, cdc25A | (40) |
| Heart | ||
| miR-21 | SPRY1 | (50,51) |
| miR-29 | Collagens | (17) |
| miR-30? | CTGF | (48) indirect† |
| miR-1/133 | ERG, RhoA, Cdc42, WHSC2, HCN1, and HCN4 | (44–47) |
| miR-320 | VEGF, FGF, IGF-1, and IGF-1R | (46) |
*H.Y.L., unpublished data.
†Inferred from the reference.