. 2011 Jun 20;60(7):1964–1972. doi: 10.2337/db11-0007

TABLE 1.

Characteristics of WT and diabetic mice at 8 weeks of diabetes (∼13 weeks old)

			Weeks of diabetes				Diabetes main effect and interaction with time
Measure	Group		2	4	6	8	P value
Body mass (g)	8 weeks + variable time post-CTX	WT	20.1 ± 0.3	23.1 ± 0.4	24.9 ± 0.4	26.2 ± 0.4	DME = 0.0004
Body mass (g)		Ins2	19.1 ± 0.3	21.5 ± 0.3^*	22.9 ± 0.4^*	23.9 ± 0.4^*	Int = 0.0035
Insulin (pg/mL)		WT	789 ± 86	778 ± 175	814 ± 106		DME <0.0001
Insulin (pg/mL)		Ins2	225 ± 24^*	224 ± 35^*	222 ± 56^*		Int = NS
Blood glucose (mmol/L)		WT	11.3 ± 0.6	9.1 ± 0.3	9.1 ± 0.3	8.2 ± 0.3	DME <0.0001
Blood glucose (mmol/L)		Ins2	29.1 ± 1.0^*	32.2 ± 0.7^*	32.4 ± 0.7^*	33.1 ± 0.5^*	Int <0.0001
Nonesterified fatty acids (mmol/L)		WT	0.63 ± 0.06	0.77 ± 0.08	1.10 ± 0.06		DME <0.0001
Nonesterified fatty acids (mmol/L)		Ins2	1.05 ± 0.10	0.85 ± 0.07	2.14 ± 0.12^*		Int = 0.0003

Biweekly data for the long-term (8 weeks) type 1 diabetic and WT groups (N = 16). Ins2^WT/C96Y mice are labeled Ins2. Two-factor ANOVA was run to determine the main effects of diabetes, time, and interaction; P values for diabetes main effect and interaction are listed next to the respective data. Absence of a significant main effect or interaction is indicated as NS.

DME, diabetes main effect; Int, interaction with time.

*Significant difference at that time point by Bonferroni post hoc comparison.