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. 2011 Jun 20;60(7):1861–1871. doi: 10.2337/db11-0030

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — FXR deficiency attenuates weight gain in ob/ob mice. A: FXR^+/+ob/ob (white bars and symbols) and FXR^−/−ob/ob mice (black bars and symbols) (n = 9 to 10/group) were monitored weekly for body weight. Significance of the overall effect of genotype (P < 0.0001) and age (P < 0.0001) as well as their interaction (P < 0.0001) was calculated by two-way ANOVA. B: Body composition was assessed by dual-energy X-ray absorptiometry in 20-week-old mice (n = 9 to 10/group). Vo₂ (C) and Vco₂ (D) were determined in 20-week-old mice (n = 5/group) individually housed in metabolic cages. Values are means ± SEM. Differences between genotypes over time were analyzed by two-way ANOVA and Bonferroni post hoc test; differences between genotypes were calculated by Mann-Whitney test (*P = 0.05, **P < 0.01, ***P < 0.001).