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. 2011 Jun 20;60(7):1861–1871. doi: 10.2337/db11-0030

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 4. — FXR deficiency in ob/ob mice results in the accumulation of plasma triglycerides. A and B: Lipid parameters were measured in plasma of 12-week-old FXR^+/+ob/ob (white bars or circles) and FXR^−/−ob/ob mice (black bars or circles) (n = 9 to 10/group). C: Lipoprotein profiles were determined in plasma pools of 13-week-old mice. D: VLDL production was assessed in 13-week-old female mice (n = 8–10/group) by measuring plasma triglyceride concentrations subsequent to Tyloxapol injection. E: Gene expression was measured by QPCR in livers of 20-week-old mice (n = 9 to 10/group). Values are means ± SEM. Differences between genotypes were calculated by Mann-Whitney test (***P < 0.001). FFA, free fatty acid; OD, optical density; TG, triglyceride.