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. 2011 Jun 20;60(7):1861–1871. doi: 10.2337/db11-0030

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 6. — Liver-specific FXR deficiency does not protect from diet-induced obesity and insulin resistance. LFXR^−/− mice and LFXR^+/+ littermates (n = 7–12/group) were fed a HFD or a control diet (CD) for 10 weeks (LFXR^+/+, white bars and symbols; LFXR^−/−, black bars and symbols). A: Body weight was monitored weekly. Significance of the effect of diet (P < 0.0001) and age (P < 0.0001) as well as their interaction (P < 0.0001) was calculated by two-way ANOVA. Plasma leptin (B) and plasma triglyceride (TG) (C) were determined at the end of the feeding period. D: Fasting blood glucose was measured weekly. Significance of the overall effect of diet (P < 0.0001) and age (P < 0.0001) as well as their interaction (P = 0.0217) was calculated by two-way ANOVA. E: Plasma insulin was measured after 6 weeks of feeding. Blood glucose excursion (F) and integrated AUC (G) after administration of an intraperitoneal glucose bolus (1 g/kg glucose) were measured after 5 weeks of feeding (n = 6/group). Values are means ± SEM. Differences between diet groups over time were analyzed by two-way ANOVA and Bonferroni post hoc test; differences between genotypes or diet groups were calculated by Mann-Whitney test. *Compares genotypes of the same diet group; $compares diet groups for LFXR^+/+; §compares diet groups for LFXR^−/− ($ or §P < 0.05; **, $$, or §§P < 0.01; $$$ or §§§P < 0.001).