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. 2011 Jun 20;60(7):1861–1871. doi: 10.2337/db11-0030

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 7. — Modulation of BA metabolism does not affect glucose homeostasis in FXR^−/−ob/ob mice. FXR^+/+ob/ob and FXR^−/−ob/ob mice (10 weeks old) were administered 2% colesevelam mixed in the diet or plain diet for 3 weeks (n = 13/group) (FXR^+/+ob/ob control, white bars or circles; FXR^+/+ob/ob treated, horizontally hatched bars or white squares; FXR^−/−ob/ob control, black bars or circles; FXR^−/−ob/ob treated, diagonally hatched bars or black squares). A: TGR5 target gene expression was measured by QPCR in BAT of 20-week-old mice (n = 9 to 10/group). B: Plasma BA were measured after 9 days of treatment. C: Body weight was monitored weekly during the treatment period. Significance of the overall effect of treatment (P < 0.0001) and age (P = 0.0002) was calculated by two-way ANOVA. D: Fasting blood glucose was determined weekly during the treatment period. Blood glucose excursion (E) and integrated AUC (F) after administration of an intraperitoneal glucose bolus (1 g/kg glucose) were measured at the end of the treatment period. G: Plasma insulin was measured at the end of the treatment period. Values are means ± SEM. Differences between treatment groups over time were analyzed by two-way ANOVA and Bonferroni post hoc test; differences between genotypes or treatment groups were calculated by Mann-Whitney test. *Compares genotypes of the same treatment group; $compares treatment groups of the same genotype (* or $P < 0.05, ** or $$P < 0.01, ***P < 0.001).