FIGURE 6.
TRPM7-like current and the effect of infection with shRNATRPM7. A, typical currents of a control neuron perfused with low Ca2+, no added Mg2+ solution, divalent cation-free external solution, or choline-substituted Na+-free external solution without divalent cations. B, reduction of the relative outwardly rectifying current recorded in control neuron by 10 μmol/liter Gd3+; all values at different points were normalized to the response induced by voltage ramp in low Ca2+, no added Mg2+ solution (n = 5, *, p < 0.05). C, typical currents of neurons treated with shRNAControl and shRNATRPM7. D, decrease in current density of shRNATRPM7 treated neurons versus control (n = 9 for shRNAcontrol, n = 4 for shRNATRPM7; *, p < 0.05).