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. 2011 Apr 18;286(23):20423–20430. doi: 10.1074/jbc.M111.235044

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — HMGCS2 regulates FGF21 expression in HepG2 cell line. A, FGF21 mRNA levels of cells infected with adenoviruses expressing GFP (AdGFP), wild type (AdHMGCS2 WT), or C166A dead mutant (AdHMGCS2 MUT) human HMGCS2. B, FGF21 mRNA levels of HepG2 transfected with siRNA control siRNA (nontargeting) or specific siRNA against HMGCS2 and infected with adenoviruses expressing GFP (left panel) or human PPARα (AdPPARα; right) is shown. The results are expressed as the percentages of induction by PPARα in the presence of HMGCS2 (100%) or in the absence of HMCGC2. The average of five independent experiments is shown. *, p < 0.05, **, p < 0.01.