TABLE 2.
Susceptibility of HIV-1 constructs to AZT, d4T, and Foscarnet
The IC50 values represent the mean ± S.D. of at least three tests, with each one performed six times. The fold increase in IC50 relative to the wild-type HXB2 virus control carrying the RT sequence of NL4–3 is shown in parenthesis.
| RTs | IC50 |
||
|---|---|---|---|
| AZT | d4T | Foscarnet | |
| nm | nm | nm | |
| WT (NL4-3) | 5.4 ± 1.1 | 274.6 ± 44.5 | 44637 ± 10687 |
| Δ67/T69G/K70R | 47.0 ± 6.3 (8.7) | 451.8 ± 60.3 (1.6) | 119068 ± 16753 (2.7) |
| Δ67/T69G/K70R/K219E | 57.5 ± 24.3 (10.6) | 390.5 ± 109.5 (1.4) | 27772 ± 4942 (0.6) |
| Δ69 | 2.5 ± 0.7 (0.4) | 231.8 ± 103.9 (0.8) | 31133 ± 5428 (0.7) |
| Δ69/K219E | 2.5 ± 0.4 (0.4) | 294.0 ± 87.8 (1.1) | 21260 ± 1357 (0.5) |
| S68G/Δ69/K70G | 3.7 ± 1.1 (0.7) | 295.1 ± 83.7 (1.1) | 33138 ± 6976 (0.7) |
| S68G/Δ69/K70G/K219E | 8.0 ± 1.3 (1.5) | 394.9 ± 111.0 (1.4) | 40265 ± 8148 (0.9) |