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A schematic of interrelationship between MAC, CCL2, and VEGF during laser-induced CNV. Laser treatment leads to complement activation within the posterior segment of the eye which results in MAC deposition within the laser spots. MAC facilitates choroidal angiogenesis by directly up-regulating VEGF or by up-regulating VEGF through CCL2. Our data suggest that there are reciprocal interactions between CCL2 and VEGF.
