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Nuclear EGFR regulates BCRP/ABCG2 expression in A431/GR cells. A, mRNA and protein expressions of BCRP/ABCG2 in A431 and A431/GR cells transfected with control or EGFR siRNA were analyzed by RT-PCR and WB, respectively. B and C, effects of Akt inhibitor VIII (B) and Akt siRNA (C) on the BCRP/ABCG2 protein expression in A431/GR cells were examined by WB. N.S., non-specific siRNA.
