TABLE 2.

Correlation between gene expression and STAT2/P-STAT2 occupation of ISRE sites

			STAT2 occupancyb	P-STAT2 occupancyb	n°genes	%
Activateda	n° genes	% total
	42	55.3%	Pos-pos	Pos-pos	10	23.8%
			Pos-pos	Neg-pos	12	28.6%
			Pos-pos	Pos-neg	1	2.4%
			Pos-pos	Neg-neg	2	4.8%
			Neg-pos	Neg-pos	8	19%
			Neg-pos	Neg-neg	4	9.5%
			Pos-neg	Neg-neg	2	4,8%
			Neg-neg	Neg-neg	3	7.1%
Represseda	n° genes	% total
	23	30.2%	Pos-pos	Neg-pos	6	26%
			Pos-pos	Neg-neg	4	17.4%
			Pos-neg	Neg-neg	2	8.7%
			Neg-pos	Neg-pos	6	26%
			Neg-pos	Neg-neg	2	8.7%
			Neg-neg	Neg-neg	3	13.2%

^a Genes modulated in Huh7 cells exposed to 1000 IU/ml IFNα for 2, 4, and 8 h were divided into three categories: activated, repressed, and not changed (see “Experimental Procedures” for more details).

^b All combinations of STAT2/P-STAT2 occupancy at their ISRE sites are listed for activated and repressed ISGs. The frequency of each “ISRE occupancy group” is expressed both as absolute number of genes and as percentage within each category.