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. 2011 Apr 25;286(23):20547–20557. doi: 10.1074/jbc.M111.230151

FIGURE 4.

FIGURE 4.

Tpn1–87 alters the peptide binding specificity of HLA-A*02:01 to a minor extent. The peptide binding specificity of HLA-A*02:01 was tested using PSCPLs and shown for substitution positions 2 and 9 in the peptide. Log values of RB values (X9 EC50/sublibrary EC50) are plotted on the y axis, and the amino acid substitutions are shown on the x axis. Amino acid substitutions leading to RB values above 0.3 (log(2)) are considered favored, and values below −0.3 (log(0.5)) are considered unfavored (these boundaries are indicated by the gray shading). Significant differences (p < 0.05) are marked with an asterisk.