FIGURE 7.

New Model for Recruitment of Dynein to Kinetochores. Previous work suggested that phosphorylated dynein was recruited to kinetochores through a direct interaction with the rod-zw10-zwilch complex (1). However, the requirement for phosphorylation was difficult to test without kinase candidates. This study identifies Plk1 as a mitotic dynein kinase that is required for recruitment of phospho-dynein. This study provides a novel method to separate the contributions of dynactin from those of dynein alone. It also has implications for the application of Plk1 inhibition as an anti-cancer therapy.