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. Author manuscript; available in PMC: 2011 Jun 23.
Published in final edited form as: Curr Opin Biotechnol. 2010 Jun 18;21(4):439–476. doi: 10.1016/j.copbio.2010.05.002

Figure 4.

Figure 4

Schematic drawing illustrating the principle of resistive-pulse sensing of analytes (green sphere) with α-hemolysin pores. The pores are engineered to contain an artificial binding site for the analyte in their lumen. In the presence of a transmembrane potential, binding of an analyte molecule results in a partial blockage of the pore; this modulation can be detected by the fluctuations in the ionic current passing through the pore. Figure reprinted from reference [3••] with permission.