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. Author manuscript; available in PMC: 2011 Jun 23.
Published in final edited form as: Curr Opin Biotechnol. 2010 Jun 18;21(4):439–476. doi: 10.1016/j.copbio.2010.05.002

Figure 6.

Figure 6

Resistive-pulse sensing through protein pores (here α-hemolysin) makes it possible to determine the size of polymers in solution as well as to monitor the kinetics of polymer chain elongation. (a) Polymers of different molecular weight translocating through a protein pore result in transient current blockages of different magnitude. Figure adapted form reference [222] with permission. (b) Polymers that are linked covalently to the interior of a protein pore can be used to observe chemical reactions that lead to the addition of individual monomers; each added monomer decreases the current through the pore.