Table 2.
Selected SNPs in the CHRNA3-CHRNA5-CHRNB4 cluster in relation to PD1
SNPs | Minor allele frequency |
All participants |
Never smokers |
Ever smokers |
||||
---|---|---|---|---|---|---|---|---|
of controls | of cases | OR (95% CI)2 | P | OR (95% CI)2 | P | OR (95% CI)2 | P | |
rs8034191 | 0.33 | 0.34 | 1.08 (0.93–1.25) | 0.3 | 1.18 (0.93–1.49) | 0.2 | 1.01 (0.84–1.22) | 0.9 |
rsl7486278 | 0.33 | 0.34 | 1.06 (0.92–1.23) | 0.4 | 1.14 (0.90–1.43) | 0.3 | 1.01 (0.83–1.22) | 0.9 |
rs569207 | 0.24 | 0.25 | 1.05 (0.90–1.22) | 0.6 | 0.91 (0.71–1.17) | 0.5 | 1.18 (0.97–1.44) | 0.1 |
rsl6969968 | 0.33 | 0.34 | 1.07 (0.92–1.23) | 0.4 | 1.16 (0.92–1.46) | 0.2 | 1.00 (0.83–1.21) | 0.98 |
rs578776 | 0.29 | 0.29 | 1.00 (0.86–1.16) | 0.96 | 0.85 (0.67–1.08) | 0.2 | 1.12 (0.93–1.35) | 0.3 |
rsl051730 | 0.32 | 0.34 | 1.07 (0.93–1.24) | 0.3 | 1.16 (0.92–1.46) | 0.2 | 1.02 (0.84–1.23) | 0.9 |
rs6495308 | 0.24 | 0.25 | 1.03 (0.89–1.21) | 0.7 | 0.89 (0.69–1.15) | 0.4 | 1.17 (0.96–1.43) | 0.1 |
The numbers of cases/controls for each analysis were: 788/911 for all participants, 363/318 for never smokers, 418/590 for ever smokers.
ORs (95% CI) for PD per risk allele under the additive model.