Table 2.
Effect of EGCG treatment on the number of surviving motoneurons and percentage of cell loss in the lesioned side of DMN and HN at 3, 7, 14 and 28 days following PNCI
| Days postoperative | Hypoglossal nucleus | ||||
|---|---|---|---|---|---|
| Sham | Saline | EGCG (10 mg/kg) |
EGCG (25 mg/kg) |
EGCG (50 mg/kg) |
|
| 3 | 1416 ± 11 | 1405 ± 8 | 1408 ± 9 | 1398 ± 8 | 1399 ± 9 |
| - | 1 ± 0.6% | 1 ± 0.6% | 1 ± 0.8% | 1 ± 0.9% | |
| 7 | 1408 ± 10 | 1294 ± 18 | 1304 ± 17 | 1360 ± 11* | 1365 ± 7* |
| - | 9 ± 1.7% | 8 ± 1.9% | 4 ± 1.2%* | 4 ± 1.0%* | |
| 14 | 1411 ± 11 | 1212 ± 31 | 1238 ± 20 | 1318 ± 10* | 1331 ± 7* |
| - | 14 ± 2.0% | 12 ± 2.0% | 7 ± 1.0%* | 6 ± 1.0%* | |
| 28 | 1397 ± 8 | 1165 ± 20 | 1175 ± 30 | 1291 ± 5* | 1301 ± 5* |
| - | 18 ± 2.0% | 17 ± 2.0% | 9 ± 1.0%* | 8 ± 1.0%* | |
| Days postoperative | Dorsal motor nucleus of vagus nerve | ||||
| Sham | Saline |
EGCG (10 mg/kg) |
EGCG (25 mg/kg) |
EGCG (50 mg/kg) |
|
| 3 | 1284 ± 10 | 1277 ± 13 | 1286 ± 8 | 1293 ± 8 | 1289 ± 7 |
| - | 1 ± 0.5% | 0 ± 0.7% | 0 ± 0.6% | 0 ± 0.7% | |
| 7 | 1292 ± 8 | 1182 ± 19 | 1185 ± 16 | 1227 ± 11* | 1235 ± 8* |
| - | 8 ± 1.5% | 8 ± 1.6% | 4 ± 0.7%* | 4 ± 0.7%* | |
| 14 | 1289 ± 11 | 1055 ± 20 | 1079 ± 14 | 1182 ± 13* | 1192 ± 7* |
| - | 18 ± 1.3% | 16 ± 1.4% | 8 ± 0.7%* | 7 ± 1.0%* | |
| 28 | 1283 ± 8 | 952 ± 21 | 983 ± 17 | 1021 ± 15* | 1091 ± 27* |
| - | 26 ± 1.2% | 23 ± 1.4% | 20 ± 1.3%* | 15 ± 2.3%* | |
*, p < 0.05 when compared with the saline-treated group