Table 1.
In vitro profile of the NEP/NPs and NFκB/UPS pathways in PC
| AD | AI | |
|---|---|---|
| LnCaP | PC-3 | |
| NEP specific activity (pmoles/μg/min) | 187.25 | 0.375 |
| NEP surface expression (%) | 98.89 | 3.81 |
| NEP protein | High | None |
| ET-1 secretion (pg/ml) | 1.44 | 4.95 |
| NFκB subcellular localisation | Cytoplasmic | Mixed |
| Nuclear NFκB protein | Low | High |
| NFκB-DNA binding signal | Low | Intense |
| Total cellular IκBα protein | High | Low |
| 20S proteasomal activity (RFU/μg) | 45.2 | 208.58 |
Analysis of components of the two pathways in cell line models of AD and AI states.