Table 5.
Potential transcription factor binding sites within the PRDX6 gene
| SNP | Location | Base Change | Reference Sequence | Alternative Sequence |
|---|---|---|---|---|
| PRDX6_171709541 | 5' UTR | G/C | n/a | Sp1, CACCC binding factor, PuF |
| rs13376447 | 5' UTR | A/G | GATA-1 | GATA-1 |
| PRDX6_171709910 | 5' UTR | G/T | n/a | IL-6 RE-BP |
| rs10753081 | 5' UTR | C/T | GATA-3 | GATA-1 |
| PRDX6_171710327 | 5' UTR | C/T | C/EBPbeta | C/EBPbeta |
| PRDX6_171710775 | 5' UTR | G/C | c-Myb | n/a |
| rs9425722 | 5' UTR | C/T | n/a | c-Myc |
| rs35152701 | 5' UTR | A/G | n/a | TMF, TBP, TFIID |
| rs12739142 | 5' UTR | A/G | IPF1, Isl-1, IPF1 | IPF1 |
| rs4354572 | 5' UTR | C/T | C/EBPbeta | AFP1, ATBF1-B |
| rs11576174 | 5' UTR | G/T | H4TF-1 | ETF, TMF, TFIID, TBP |
| PRDX6_171712345 | 5' UTR | A/T | n/a | SRY, TCF-4E |
| PRDX6_171712345 | 5' UTR | A/T | n/a | SRY |
| rs35441546 | 5' UTR | C/T | Sp1, ETF | CACCC-binding factor, Sp1 |
| rs35133735 | 5' UTR | C/T | n/a | CACCC-binding factor, Sp1 |
| rs6671141 | intron | G/T | GR alpha, PR, PR A, GR beta | n/a |
| PRDX6_171713738 | intron | G/T | n/a | TEF-1 |
| PRDX6_171713872 | intron | C/T | n/a | H4TF-1 |
| rs35918328 | intron | A/G | IPF1 | n/a |
| rs33942654 | intron | A/G | c-Myb | n/a |
| PRDX6_171714984 | intron | C/T | TBP | GATA-1 |
| PRDX6_171715019 | intron | A/G | GATA-3 | GATA-1 |
| rs9425723 | intron | A/G | TBP, TFIID | AP-1, c-Jun |
| rs9425724 | intron | A/G | USF1 | AP-1, AP-4, CCK-1a, c-Myc, CREB, Max1, USF1 |
| PRDX6_171715596 | intron | A/G | c-Myb, c-Ets-2 | n/a |
| PRDX6_171716007 | intron | A/G | n/a | Sp1, C/EBPbeta, CACCC-binding factor |
| PRDX6_171716572 | intron | A/T | TMF, TFIID, ETF, TBP | n/a |
| PRDX6_171716582 | intron | A/G | GATA-1, GATA-3 | n/a |
| PRDX6_171716584 | intron | A/T | GATA-1, GATA-3 | SRY |
*Transcription factor binding site modeling was performed using TESS.