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Incidence of adverse events
| Spironolactone users | Spironolactone non-users | |
|---|---|---|
| Hyperkalemia | 408/12,344 (3.3%) |
955/69,674 (1.4%)* |
| Breast complications in men | 158/6,368 (2.5%) |
380/32,764 (1.2%)* |
| Breast hypertrophy in men (gynecomastia) | 117/6,368 (1.8%) |
233/32,764 (0.7%)* |
* p < 0.001 (Pearson's chi square test)
