Table 1. Scoring templates for overt- and non-overt (NO) disseminated intravascular coagulation (DIC) in patients with hemorrhagic fever with renal syndrome.

	Score	DIC1	DIC2	DIC3a	DIC4b	Score	NO-DIC1	NO-DIC2
Platelet count, 109/L	2	<50	<50	<50	<50	1	<100
	1	50–100	50–100	50–100	50–100	0	>100
	0	>100	>100	>100	>100
D-dimer, mg/L	3	>2.0	>2.48	>2.0	>2.48	1	≥0.2	≥0.64
	2	0.2–2.0	0.64–2.48	0.2–2.0	0.64–2.48	0	<0.2	<0.64
	0	<0.2	<0.64	<0.2	<0.64
PK-INR c	2	>1.4	>1.4	>1.4	>1.4	1	≥1.2
	1	1.2–1.4	1.2–1.4	1.2–1.4	1.2–1.4	0	<1.2
	0	<1.2	<1.2	<1.2	<1.2
Fibrinogen, g/L	1	<1.0	<1.0
	0	≥1.0	≥1.0
Fibrinogen/CRP-ratio	1			<104	<104	Falling values add 1 point and rising
	0			≥104	≥104	values subtract 1 point for PK and
						D-dimer (vice versa for platelets)

DIC1 and NO-DIC1 correspond to standard ISTH scoring using local decision limit. DIC—2 and NO-DIC-2 uses D-dimer cut-offs based on ICU-patients. DIC3-4 are corrected with a fibrinogen/CRP-ratio instead of fibrinogen.

The original ISTH SSC template uses “moderately” and “strongly” increased values for D-dimer cutoffs [35]. In this table laboratory cutoffs are set from local decision limits and also corrected with a fibrinogen/CRP ratio [37]. Overt DIC-score ≥5p: compatible with overt DIC, <5p: suggestive for non-overt DIC.

^aD-dimer cutoff as in DIC1, fibrinogen corrected with fibrinogen/CRP-ratio.

^bD-dimer cutoff as in DIC2, fibrinogen corrected with fibrinogen/CRP-ratio.

^cPK-INR <1.2 was equal to PT-prolongation <3 sec, a value between 1.2 and 1.4 was equal to PT-prolongation >3 but <6 sec, and values >1.4 were equal to PT-prolongation >6 sec.