Table 2. Comparison of laboratory and clinical parameters in patients with moderate/severe vs. mild hemorrhagic fever with renal syndrome.
| All (n = 106) | Moderate/severe illness, (n = 13) | Mild illness (n = 93) | p valuea | |
| Age, years b | 53 (40–64) | 64 (55–74.5) | 51 (38.5–51.5) | 0.011 |
| Gender, female/male, n (%) | 58/48 (54.7/45.3) | 7/6 (53.8/46.2) | 51/42 (54.8/45.2) | 0.946 |
| Laboratory data at score c | ||||
| Platelet count, ×109/L | 95 (17–404) | 38 (17–268) | 100 (19–404) | 0.001 |
| D-dimer, mg/L | 0.70 (0.12–5.31) | 0.90 (0.61–5.31) | 0.66 (0.12–3.69) | 0.021 |
| PK-INR | 1.1 (0.9–1.5) | 1.1 (0.9–1.5) | 1.0 (0.9–1.4) | 0.041 |
| Fibrinogen, g/L | 4.66 (1.57–32.0) | 4.02 (1.57–8.42) | 4.66 (2.25–32.0) | 0.137 |
| Fibrinogen/CRP ratio | 83.2 (16.4–538.6) | 68.6 (28.3–162.0) | 85.0 (16.4–538.6) | 0.242 |
| CRP, mg/L | 57 (7–236) | 56 (29–169) | 58 (7–236) | 0.686 |
| Creatinine, µmol/L | 133 (37–1548) | 245 (67–1034) | 126 (37–1548) | 0.010 |
| Clinical data, n (%) | ||||
| Mild bleeding | 27 (25.5) | 3 (23.1) | 24 (25.8) | 0.833 |
| Moderate/severe bleeding | 9 (8.5) | 3 (23.1) | 6 (6.5) | 0.045 |
| Need for intensive care | 5 (4.7) | 5 (38.5) | 0 | <0.001 |
| Dialysis | 1 (0.9) | 1 (7.7) | 0 | 0.007 |
| Thrombosis | 3 (2.8) | 3 (23.1) | 0 | <0.001 |
| Need for oxygen | 15 (14.2) | 9 (69.2) | 6 (6.5) | <0.001 |
| Thrombocyte transfusion | 11 (10.4) | 5 (38.5) | 6 (6.5) | <0.001 |
| Days at hospital, nd | 3 (0–55) | 11 (4–55) | 3 (0–13) | <0.001 |
| Systolic blood pressure, mmHge | 120 (80–180) | 110 (80–160) | 120 (90–180) | 0.085 |
a
Calculated using Mann-Whitney U and χ2 test.
b
Value given as median, 25th and 75th percentiles within parentheses.
c
Value given as median, range within parentheses.
d
Value given as median, range within parentheses.
e
Median value at the day of DIC-scoring (n = 88).