Table 4. Top MAM-associated brain KEGG pathways.
| Top KEGG Pathways | Genes | Phenotype |
| Pathways in cancer | 13 | CC |
| Wnt signaling | 10 | AD, CC, skin, bone |
| Insulin signaling | 9 | AD, ALS |
| Purine metabolism | 9 | |
| Prostate cancer | 8 | CC |
| MAPK signaling | 7 | AD, CC |
| Melanogenesis | 6 | PD? CC |
| Neurotrophin signaling | 6 | AD |
| Focal adhesion | 6 | AD, CC |
| Chemokine signaling | 5 | AD |
| Neuroactive ligand-receptor interaction | 5 | AD |
| Calcium signaling pathway | 4 | AD, CC |
Top brain KEGG pathways (derived from 443 MAM-modulated genes, see Table 3) and the number of MAM-modulated genes and human diseases associated with each pathway. Note the prominent involvement of the Wnt, insulin and MAPK signaling pathways, in addition to the presence of pathways involved in inflammatory and other responses. AD: Alzheimer disease. ALS: Amyotrophic lateral sclerosis. CC: Colon cancer. PD: Idiopathic Parkinson's disease.