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. Author manuscript; available in PMC: 2012 May 5.
Published in final edited form as: DNA Repair (Amst). 2011 Mar 22;10(5):497–505. doi: 10.1016/j.dnarep.2011.02.003

Table 3. Replicative polymerase error specificity within the [GT/CA]10 microsatellite.

Microsatellite/
Mutational
Events
Proportion of Events (number observed)

Polδ Polε


WT Exo- WT Exo-


[GT]10
Unit-based InDel 0.82 (62) 0.73 (53) 0.96 (53) 0.52 (12)
 Deletion 0.82 (62) 0.73 (53) 0.93 (51) 0.52 (12)
  1 unit 0.65 (49) 0.49 (36) 0.73 (40) 0.30 (7)
  > 1 unit 0.17 (13) 0.23 (17) 0.20 (11) 0.22 (5)

 Insertion 0 0 0.04 (2) a 0

Interruption 0.18 (14) 0.26 (19) 0.04 (2) 0.48 (11)

[CA]10
Unit-based InDel 1.0 (79) 0.92 (65) 1.0 (49) 0.93 (40)
 Deletion 0.92 (73) 0.92 (65) 0.84 (41) 0.84 (36)
  1 unit 0.61 (48) 0.66 (47) 0.65 (32) 0.74 (32)
  > 1 unit 0.32 (25) 0.25 (18) 0.18 (9) 0.09 (4)

 Insertion 0.08 (6) 0 0.16 (8) 0.09 (4)
  1 unit 0.05 (4) 0.10 (5) 0.05 (2)
  > 1 unit 0.03 (2) 0.06 (3) 0.05 (2)

Interruption 0 0.08 (6) 0 0.07 (3)
a

All mutants were 1 unit changes