Table 3. Replicative polymerase error specificity within the [GT/CA]10 microsatellite.
Microsatellite/ Mutational Events |
Proportion of Events (number observed) | |||
---|---|---|---|---|
Polδ | Polε | |||
WT | Exo- | WT | Exo- | |
[GT]10 | ||||
Unit-based InDel | 0.82 (62) | 0.73 (53) | 0.96 (53) | 0.52 (12) |
Deletion | 0.82 (62) | 0.73 (53) | 0.93 (51) | 0.52 (12) |
1 unit | 0.65 (49) | 0.49 (36) | 0.73 (40) | 0.30 (7) |
> 1 unit | 0.17 (13) | 0.23 (17) | 0.20 (11) | 0.22 (5) |
Insertion | 0 | 0 | 0.04 (2) a | 0 |
Interruption | 0.18 (14) | 0.26 (19) | 0.04 (2) | 0.48 (11) |
[CA]10 | ||||
Unit-based InDel | 1.0 (79) | 0.92 (65) | 1.0 (49) | 0.93 (40) |
Deletion | 0.92 (73) | 0.92 (65) | 0.84 (41) | 0.84 (36) |
1 unit | 0.61 (48) | 0.66 (47) | 0.65 (32) | 0.74 (32) |
> 1 unit | 0.32 (25) | 0.25 (18) | 0.18 (9) | 0.09 (4) |
Insertion | 0.08 (6) | 0 | 0.16 (8) | 0.09 (4) |
1 unit | 0.05 (4) | 0.10 (5) | 0.05 (2) | |
> 1 unit | 0.03 (2) | 0.06 (3) | 0.05 (2) | |
Interruption | 0 | 0.08 (6) | 0 | 0.07 (3) |
All mutants were 1 unit changes