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. 2011 Jun 23;7(6):e1002154. doi: 10.1371/journal.pgen.1002154

Figure 4. Gene expression level-dependent 5-hmC and H3K36me3 distributions in human ES cells.

Figure 4

A. Gene expression values (RPKM) obtained from [16] were ranked in descending order, and 5-hmC and H3K36me3 read densities were measured in 100-bp bins ±5 kb of the TSS or TES. Values were normalized to the total number of aligned reads in millions. The scale of 5-hmC and H3K36me3 signals are indicated at the below each respective heatmap. B. 5-hmC and input read densities at the top 25% of genes based on RPKM expression level. C. 5-hmC and input read densities among genes expressed within the 25–50% range of all genes based on RPKM expression level. D. 5-hmC and input read densities among genes expressed within the 50–75% range of all genes based on RPKM expression level. E. 5-hmC and input read densities at the bottom 25% of genes based on RPKM expression level. For B–E, reads were summed in 10-bp windows 2.5 kb upstream and downstream of TSS and TES.