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Structure of the hGTase domain of hCE. hGTase has an ATP-grasp fold domain with two subdomains (green and blue) and an OB-fold domain (orange). The secondary structural elements (1–15 β-strands and A–G α-helices) are labeled. The GTP sits between the blue and green subdomains with the phosphates pointing to the cleft. The conserved residue K294 forms a phosphoamide-linked GMP intermediate with the removal of PPi, followed by transfer of the GMP to the diphosphate-ended pre-mRNA.
