Table 4.

Loss of Anp32b reveals a moderate viability defect attributable to Anp32a

	Anp32b+/+			Anp32b+/−			Anp32b−/−
	Anp32a+/+	Anp32a+/−	Anp32a−/−	Anp32a+/+	Anp32a+/−	Anp32a−/−	Anp32a+/+	Anp32a+/−	Anp32a−/−
Mendelian	10	20	10	20	41	20	10	20	10
Expected	15	30	15	23	45	23	3	6	3
Observed*	15	25	20	28	43	23	8	0	0

Numbers of double-mutant mice of the indicated genotypes arising from the intercrossing of Anp32a^+/−;Anp32b^+/− mice. “Mendelian” indicates the distribution for the indicated total number of mice under conditions of normal Mendelian segregation. “Expected” indicates the distribution for the Mendelian distributed numbers with integration of the observed rates of Anp32b lethality (Table 1). “Observed” indicates the actual numbers of mice of the noted genotypes obtained. Statistical probability is calculated against “Expected” ratios.

*P < 0.01 by χ² analysis.