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. 2011 Jun 1;108(25):10361–10366. doi: 10.1073/pnas.1101400108

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Fig. 1. — Urine-concentrating ability of Kir5.1^+/+ and Kir5.1^−/− mice. Daily diuresis (A) and urine osmolality (B) of Kir5.1^+/+ (□) and Kir5.1^−/− (■) mice maintained in metabolic cages were first measured while the mice had free access to demineralized water (+H₂O), and then after a 24-h period of water deprivation (−H₂O). Weight loss induced by water deprivation averaged 7% and 9% for Kir5.1^+/+ and Kir5.1^−/− mice, respectively. Water deprivation tests showed that both groups of mice had similar urine-concentrating abilities. Values are mean values for 10 Kir5.1^+/+ and eight Kir5.1^−/− mice. Error bars represent SEM when larger than symbols. *P < 0.05, Kir5.1^−/− versus Kir5.1^+/+ mice.