Table 1.
Biological parameters in Kir5.1+/+ and Kir5.1−/− mice
| Parameter | Kir5.1+/+ (n = 11) | Kir5.1−/− (n = 10) |
| Total BW, g | 27.9 ± 0.26 | 24.7 ± 0.57* |
| Water intake, μL/g BW/d | 167 ± 16 | 228 ± 14† |
| Systolic blood pressure, mm Hg | 109.8 ± 2.4 | 104 ± 2.6 |
| Urine | ||
| Uv, μL/g BW/d | 52 ± 11 | 105 ± 14† |
| Osmolality, mOsm/kg H2O | 2598 ± 247 | 1718 ± 167† |
| pH | 5.62 ± 0.04 | 5.68 ± 0.04 |
| Na+, mmol/mmol creatinine | 75.3 ± 4.8 | 67.6 ± 2.7 |
| K+, mmol/mmol creatinine | 8.23 ± 1.45 | 14.36 ± 1.77‡ |
| Cl−, mmol/mmol creatinine | 137.4 ± 10.2 | 136 ± 5.6 |
| Ca2+, mmol/mmol creatinine | 0.43 ± 0.06 | 1.82 ± 0.35‡ |
| Mg2+, mmol/mmol creatinine | 2.68 ± 0.25 | 3.42 ± 0.2§ |
| Aldosterone, μmol/mmol creatinine | 3.38 ± 0.54 | 2.71 ± 0.4 |
| Blood | ||
| pH | 7.35 ± 0.0.015 | 7.19 ± 0.015* |
| PCO2, mm Hg | 45.5 ± 1.1 | 45.7 ± 1.4 |
| [HCO3−], mM | 24.4 ± 0.5 | 16.9 ± 0.3* |
| Plasma | ||
| Osmolality (mOsm/kg H2O) | 305 ± 1.7 | 303 ± 5.2 |
| [Cl−], mM | 122.5 ± 0.7 | 130.6 ± 0.8* |
| [Na+], mM | 149.8 ± 2.4 | 153.1 ± 0.5 |
| [K+], mM | 4.4 ± 0.14 | 3.9 ± 0.12‡ |
| [Ca2+], mM | 1.26 ± 0.007 | 1.27 ± 0.009 |
| [Mg2+], mM | 1.66 ± 0.15 | 1.53 ± 0.37 |
Values are mean ± SEM for the numbers of animals given in brackets, except for fractional excretions in Kir5.1−/− mice, where n = 7, for plasma K+ concentration of Kir5.1+/+ and Kir5.1−/− mice, where n = 9 and n = 6, respectively, and for diastolic blood pressure of Kir5.1+/+ mice, where n = 12.
*P < 0.0001, †P < 0.005, ‡P < 0.05, and §P < 0.01.