Fig. 7.

OSN axon targeting is perturbed in Bbs8^−/− mice. The OR reporter line M72^TL was crossed into a Bbs8 mutant background and axon targeting was analyzed by whole-mount X-Gal staining of PD15 mice. In dorsal views, axons project from the OE (on the bottom) to their targets in the OB. In Bbs8^+/+ mice, M72-tau:lacZ–expressing axons converge to one dorsal glomerulus in each bulb. In the OB of Bbs8-deficient mice, multiple glomeruli are innervated and individual fibers wander on the surface of the bulb.