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LpxC inhibitors block the RB to EB developmental transition. C. trachomatis infected HeLa cells were incubated in media with DMSO only (Upper) or 1.92 μg/mL of LPC-009 (Lower). At 36 hpi, cells were fixed and processed for transmission electron microscopy. EB, elementary bodies; IB, intermediate bodies; RB, reticulate bodies. Note misshapen EB and IB in the inhibitor-treated samples.
