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. Author manuscript; available in PMC: 2011 Jun 23.
Published in final edited form as: Cancer Biomark. 2010 Jan 1;7(4):173–188. doi: 10.3233/CBM-2010-0188

Fig. 5.

Fig. 5

Additional value of CT in 18F-FHBG PET images of metastasis. (A) Thirty-five days after intraventricular injection of 1.5 × 106 A375M-3F melanoma cells in nude mouse, 18F-FHBG PET/CT allows precise anatomic localization of metastasis in interscapular fat (a), right eye (b), right humeral head (c), and left mandibula (d) as shown by green arrows. Lack of anatomic landmarks on PET alone is illustrated by white arrows. (B) BLI shows same lesions as seen on 18F-FHBG PET/CT but does not provide information on depth of lesion. (C) Ex vivo thymidine kinase and luciferase assays of lesions (1) and contralateral controls (2) validate imaging observations. Reprinted with permission from [92].