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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Int Immunopharmacol. 2011 Mar 5;11(8):1038–1044. doi: 10.1016/j.intimp.2011.02.024

Figure 1. Levels of BAL and lung eosinophils in TNF-R deficient vs WT mice.

Figure 1

TNF-R deficient or WT mice were subjected to chronic OVA challenge. Non-OVA challenged mice served as a control. Eosinophils in bronchoalveolar lavage (BAL) were quantitated in cytospin slides stained with Wright-Giemsa, whereas eosinophils in lung sections were quantitated by immunostaining with an anti-MBP Ab. Chronic OVA challenge in WT mice induced a significant increase in BAL eosinophils (p<0.0001*)(Fig 1A), and peribronchial eosinophils (p<0.0001*)(Fig 1B)(WT no OVA vs WT OVA). Levels of eosinophils in chronic OVA challenged TNF-R deficient mice were significantly reduced compared to WT mice challenged with OVA in the BAL (p= 0.02#)(Fig 1A) and lung (p<0.0001#)(Fig 1B)(n=16 mice/group).