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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Int Immunopharmacol. 2011 Mar 5;11(8):1038–1044. doi: 10.1016/j.intimp.2011.02.024

Figure 4. Levels of peribronchial TGF-β1+ cells in TNF-R deficient vs WT mice.

Figure 4

TNF-R deficient or WT mice were subjected to chronic OVA challenge. Non-OVA challenged mice served as a control. Lung sections were immunostained with an anti-TGF-β1 Ab and the number of peribronchial TGF-β1+ cells determined by image analysis. Chronic OVA challenge in WT mice induced a significant increase in the number of peribronchial TGF-β1+ cells (p<0.0001*)(WT no OVA vs WT OVA). The number of peribronchial TGF-β1+ cells were significantly reduced in chronic OVA challenged TNF-R deficient mice compared to WT mice challenged chronically with OVA (p<0.0001#)(n=16 mice/group).