Histopathological features in AD mgb−/− kidneys. H&E staining of (A) simple cyst in renal cortex in severe kidney, 10X; (B) cystic dilation of renal tubules in severe kidney, 20X. Trichrome of (C) moderate kidney cortex with mildly to severely (arrows) dilated tubules containing numerous proteinaceous casts, 20X; (D) globally sclerotic glomeruli (circled) in severe kidney, 40X; (E) coagulation necrosis and vacuolization of tubular epithelium in moderate kidney, 40X.