Table 2.

Mean BMI values and obesity proportions of genotype groups for SNPs rs346074, rs346070, and rs3738435 among 430 antipsychotic users

Variables	No. of patients	Mean (SD)/proportion			p value β genotype	p value β interaction genotype x affinity
HRH1 rs346074	GG/GA/AA	GG	GA	AA
BMI	182/189/55	28.0 (5.2)	27.8 (5.3)	28.5 (5.0)	0.93	0.046
High aff.	83/97/28	27.5 (4.2)	27.7 (5.3)	30.1 (5.3)	0.27
Low aff.	99/92/27	28.4 (5.9)	27.9 (5.2)	26.8 (4.0)	0.10
Obesity	182/189/55	34%	30%	31%	0.58	0.005
High aff.	83/97/28	25%	30%	46%	0.14
Low aff.	99/92/27	40%	30%	15%	0.015
HRH1 rs346070	CC/CT/TT	CC	CT	TT
BMI	286/128/15	28.0 (5.1)	28.2 (5.6)	27.4 (4.8)	0.74	0.044
High aff.	139/58/12	27.6 (4.7)	29.0 (5.9)	28.5 (4.2)	0.10
Low aff.	147/70/3	28.4 (5.5)	27.5 (5.3)	22.9 (4.9)	0.22
Obesity	286/128/15	34%	29%	20%	0.22	0.009
High aff.	139/58/12	28%	38%	25%	0.36
Low aff.	147/70/3	39%	21%	0%	0.006
CHRM3 rs3738435	TT/TC/CC	TT	TC	CC
BMI	276/137/17	28.0 (5.2)	27.6 (5.2)	30.4 (5.5)	0.60	0.88
High aff.	127/57/7	27.8 (4.9)	27.8 (4.9)	30.7 (6.1)	0.33
Low aff.	149/80/10	28.3 (5.5)	27.5 (5.4)	30.2 (5.3)	0.90
Obesity	276/137/17	31%	32%	53%	0.15	0.56
High aff.	127/57/7	28%	32%	57%	0.16
Low aff.	149/80/10	34%	33%	50%	0.56

BMI (kg/m², mean and standard deviation) and obesity (%) are given per genotype group, separated in users of antipsychotics with low and high affinity for the histamine H1 receptor (in rs346074 and rs346070 high affinity clozapine, olanzapine, and quetiapine) and the muscarine M3 receptor (in rs3738435 high affinity clozapine and olanzapine).

p values are given for (1) the β of the variable genotype in linear and logistic regression, and (2) the β of the interaction term genotype x affinity in linear and logistic regression

All results are adjusted for age, gender, and population group

Genotype was tested additive in rs346074, and dominant for the minor allele in rs346070 and rs3738435

Significant p values are shown in bold