Table 3.
BMI | Haplotype (rs346074-rs346070) | β in high H1 affinity AP users | p value | β in low H1 affinity AP users | p value | β of interaction term haplotype * affinity | p value |
---|---|---|---|---|---|---|---|
G-C | – | – | – | ||||
A-C | +0.569 | 0.38 | −0.129 | 0.85 | 0.795 | 0.39 | |
A-T | +0.941 | 0.10 | −1.093 | 0.13 | 2.043 | 0.025 | |
Obesity | Haplotype (rs346074-rs346070) | e β in high H1 affinity AP users | p value | e β in low H1 affinity AP users | p value | e β of interaction term haplotype * affinity | p value |
G-C | – | – | – | ||||
A-C | 1.672 | 0.10 | 0.795 | 0.43 | 2.110 | 0.07 | |
A-T | 1.256 | 0.42 | 0.375 | 0.004 | 3.331 | 0.005 |
The unstandardized coefficients (β) of haplotype in linear regression with BMI and the odds ratios (e β) of haplotype in logistic regression with obesity are given, in high and low H1 affinity antipsychotic (AP) users, respectively
Haplotypes A-C and A-T are compared with the most frequent haplotype G-C as a reference. Haplotype G-T was not prevalent
All results are adjusted for age, gender, and population group
Significant p values are shown in bold