Table 3.

Haplotype analysis on BMI and obesity for rs346074 and rs346070 of the HRH1 gene

BMI	Haplotype (rs346074-rs346070)	β in high H1 affinity AP users	p value	β in low H1 affinity AP users	p value	β of interaction term haplotype * affinity	p value
	G-C	–		–		–
	A-C	+0.569	0.38	−0.129	0.85	0.795	0.39
	A-T	+0.941	0.10	−1.093	0.13	2.043	0.025
Obesity	Haplotype (rs346074-rs346070)	e β in high H1 affinity AP users	p value	e β in low H1 affinity AP users	p value	e β of interaction term haplotype * affinity	p value
	G-C	–		–		–
	A-C	1.672	0.10	0.795	0.43	2.110	0.07
	A-T	1.256	0.42	0.375	0.004	3.331	0.005

The unstandardized coefficients (β) of haplotype in linear regression with BMI and the odds ratios (e ^β) of haplotype in logistic regression with obesity are given, in high and low H1 affinity antipsychotic (AP) users, respectively

Haplotypes A-C and A-T are compared with the most frequent haplotype G-C as a reference. Haplotype G-T was not prevalent

All results are adjusted for age, gender, and population group

Significant p values are shown in bold