Table 6.

Published data of incidence and risk factors for CNS disease according to histologic subtype

	Diffuse large B-cell lymphomaa	Extranodal NK/T-cell lymphomab	PTCLc
Incidence	5–10%	5.76%	8.77%
Risk factors	Advanced age High IPI score Two or more extranodal involvement Paranasal sinus involvement Bone marrow involvement Testicular involvement	III/IV NKPI groupd Presence of B symptoms Advanced stage Elevated LDH level Regional lymph nodes involvement	Elevated LDH level Paranasal sinus involvement

^aBlood Rev 2006; 20: 319–332.

^bAnn Oncol 2010; 21 (5): 1058–1063.

^cThis study.

^dJ Clin Oncol 2006; 24: 612–618.

CNS, central nervous system; NK, natural killer; PTCL, peripheral T-cell lymphoma; IPI, international prognostic index; NKPI, NK/T-cell lymphoma prognostic index; LDH, lactate dehydrogenase.